作者：Catharine R. Gale, Nigel F. Hall, David
I. W. Phillips, and Christopher N.Martyn
目的：调查血浆中叶黄素和玉米黄质的浓度与老年人群中患AMD的关系。
方法：根据威斯康星AMD等级系统，将380名早期和晚期AMD的男女患者做大致的分级，这些患者均来自英国雪菲尔，年龄在66-75岁。采集禁食血样以评定血浆中叶黄素和玉米黄质的浓度。
结果：在血浆中玉米黄质浓度低的人群其AMD（包括早期和晚期）风险程度显著增高。调整年龄和其他危险因素后，相比血浆中玉米黄质最高浓度和最低浓度的人群，AMD患率危险的让步比为2.0（95％置信区间为1.0-4.1）。在血浆中玉米黄质最低浓度群和叶黄素最低浓度群中，均会增强AMD的危险率，但这些关联目前暂无统计意义。
结论：这些发现为证明玉米黄质可能防止AMD提供支持。
PURPOSE. To investigate the relation between
plasma concentrations of lutein and zeaxanthin
and age-related macular degeneration in
a group of elderly men and women.
METHODS. The Wisconsin Age-Related Maculopathy
Grading System was used to grade features
of early and late macular degeneration in
380 men and women, aged 66 to 75 years,
from Sheffield, United Kingdom. Fasting
blood samples were taken to assess plasma
concentrations of lutein and zeaxanthin.
RESULTS. Risk of age-related macular degeneration
(early or late) was significantly higher
in people with lower plasma concentrations
of zeaxanthin. Compared with those whose
plasma concentrations of zeaxanthin were
in the highest third of the distribution,
people whose plasma concentration was in
the lowest third had an odds ratio for risk
of age-related macular degeneration of 2.0
(95% confidence interval [CI] 1.0–4.1),
after adjustment for age and other risk
factors. Risk of agerelated macular degeneration
was increased in people with the lowest
plasma concentrations of lutein plus zeaxanthin
(odds ratio [OR] 1.9, 95% CI 0.9 –3.5) and
in those with the lowest concentrations
of lutein (OR 1.7, 95% CI 0.9 –3.3), but
neither of these relations was statistically
significant.
CONCLUSIONS. These findings provide support
for the view that zeaxanthin may protect
against age-related macular degeneration.
(Invest Ophthalmol Vis Sci. 2003;44:2461–2465)
DOI: 10.1167/iovs.02-0929.
